The investigators determined that there are opposite responses to exercise and obesity across all three tissues and highlight prominent molecular pathways modulated by exercise and obesity. — Updated on 2022-10-07 — Group: #Public
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Among the most striking findings, the scientists observed that genes governing extracellular modelling (ECM) and circadian rhythm were regulated by both exercise and obesity across all three tissue types. Obesity up-regulated ECM-related pathways, while exercise down-regulated them. Conversely, exercise up-regulated circadian-related pathways, and obesity down-regulated them. — Updated on 2022-10-07 — Group: #Public
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With respect to the circadian rhythm, we saw very quiet cells that weren’t metabolically active with the high-fat diet group, — Updated on 2022-10-07 — Group: #Public
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“We discovered that exercise reversed this. It seemed that, when the circadian system is upregulated, cells become re-activated.” — Updated on 2022-10-07 — Group: #Public